Determinación inmunohistoquímica de CD117/c-kit en el GIST (tumor estromal gastrointestinal)
نویسندگان
چکیده
منابع مشابه
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Gastrointestinal stromal tumors (GIST) are rare, representing less than 1% of all gastrointestinal tumors. However, this is the most frequent nonepithelial neoplasm of the digestive tract. Mean age at diagnose is 58 years old, and the two structures usually involved are stomach and bowel12. The main symptoms are abdominal pain and digestive bleeding2, while the most frequent presentation are so...
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Background. Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. The molecular mechanism of GIST formation is among the best characterized of all human tumors. Activating mutations of the c-Kit-kinase (KIT), a member of the receptor tyrosine kinase III family, are present in 80% of GISTs (Antonescu, 2011; Corless, 2011). Gain-of-function muta...
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ژورنال
عنوان ژورنال: Oncología (Barcelona)
سال: 2004
ISSN: 0378-4835
DOI: 10.4321/s0378-48352004000400023